PSME3 polyclonal antibody
产品名称： PSME3 polyclonal antibody
英文名称： PSME3 polyclonal antibody
产品编号： PAB7269
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of PSME3.
- Immunogen:
- A synthetic peptide corresponding to human PSME3.
- Sequence:
- C-KNIEKIKRPRSSN
- Host:
- Goat
- Theoretical MW (kDa):
- 29.5, 30.9
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize both reported isoforms (NP_005780.2 and NP_789839.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:132000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Relationships between autoantibody responses to deletion mutants of Ki antigen and clinical manifestations of lupus.
Matsudaira R, Takeuchi K, Takasaki Y, Yano T, Matsushita M, Hashimoto H.J Rheumatol. 2003 Jun;30(6):1208-14.
- Entrez GeneID:
- 10197
- Protein Accession#:
- NP_005780.2;NP_789839.1
- Gene Name:
- PSME3
- Gene Alias:
- Ki,PA28-gamma,PA28G,REG-GAMMA
- Gene Description:
- proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
- Omim ID:
- 605129
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq
- Other Designations:
- 11S regulator complex gamma subunit,Ki antigen,Ki nuclear autoantigen,activator of multicatalytic protease subunit 3,proteasome activator 28-gamma,proteasome activator subunit 3
- Gene Pathway