BLNK polyclonal antibody
产品名称: BLNK polyclonal antibody
英文名称: BLNK polyclonal antibody
产品编号: PAB6035
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of BLNK.
- Immunogen:
- A synthetic peptide corresponding to human BLNK.
- Sequence:
- C-KDSTRLKYAVKVS
- Host:
- Goat
- Theoretical MW (kDa):
- 50.5, 48.2
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- BLNK: a central linker protein in B cell activation.
Fu C, Turck CW, Kurosaki T, Chan AC.Immunity. 1998 Jul;9(1):93-103.
- Entrez GeneID:
- 29760
- Protein Accession#:
- NP_037446.1
- Gene Name:
- BLNK
- Gene Alias:
- BASH,BLNK-S,LY57,MGC111051,SLP-65,SLP65
- Gene Description:
- B-cell linker
- Omim ID:
- 604515
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- B cell linker protein,B-cell adapter containing a SH2 domain protein,B-cell adapter containing a Src homology 2 domain protein,OTTHUMP00000020167,Src homology 2 domain-containing leukocyte protein of 65 kDa
- Interactome
- Related Disease